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    Number of items: 38.

    Article

    Nock, Sophie H., Blanco-Lopez, Maria R. ORCID logoORCID: https://orcid.org/0009-0004-7180-2964, Stephenson-Deakin, Chloe, Jones, Sarah ORCID logoORCID: https://orcid.org/0000-0001-8154-3928 and Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 (2024) Pim Kinase Inhibition Disrupts CXCR4 Signalling in Megakaryocytes and Platelets by Reducing Receptor Availability at the Surface. International Journal of Molecular Sciences, 25 (14). ISSN 1661-6596

    Drysdale, Amelia ORCID logoORCID: https://orcid.org/0009-0002-4978-550X, Blanco-Lopez, Maria ORCID logoORCID: https://orcid.org/0009-0004-7180-2964, White, Stephen J ORCID logoORCID: https://orcid.org/0000-0003-0090-6358, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 and Jones, Sarah ORCID logoORCID: https://orcid.org/0000-0001-8154-3928 (2024) Differential proteoglycan expression in atherosclerosis alters platelet adhesion and activation. International Journal of Molecular Sciences, 25 (2). ISSN 1661-6596

    Mitchell, Joanne Khan, Dalia Rana, Rekha Kriek, Neline Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Sage, Tanya Bye, Alex et al.
    Mitchell, Joanne, Khan, Dalia, Rana, Rekha, Kriek, Neline, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Sage, Tanya, Bye, Alex, Laffan, Mike, Shapiro, Susie, Thakurta, Anjan, Grech, Henri, Ramasamy, Karthik and Gibbins, Jonathan
    (2023) Multiple myeloma and its treatment contribute to increased platelet reactivity. Platelets, 34 (1). ISSN 0953-7104

    Mitchell, Joanne L Dunster, Joanne L Kriek, Neline Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Sage, Tanya Mohammed, Yasmin MM Simone, Ilaria De et al.
    Mitchell, Joanne L, Dunster, Joanne L, Kriek, Neline, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Sage, Tanya, Mohammed, Yasmin MM, Simone, Ilaria De, Taylor, Kirk A, Bye, Alexander P, Ólafsson, Geir, Brunton, Mark, Mark, Sharon, Dymott, Leanne D, Whyte, Abigail, Ruparelia, Neil, Mckenna, Charlie, Gibbins, Jonathan M and Jones, Christopher I
    (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis, 21 (8). pp. 2248-2259. ISSN 1538-7933

    Drysdale, Amelia, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, White, Stephen J and Jones, Sarah ORCID logoORCID: https://orcid.org/0000-0001-8154-3928 (2023) The contribution of vascular proteoglycans to atherothrombosis: clinical implications. International Journal of Molecular Sciences, 24 (14). p. 11854. ISSN 1422-0067

    Kuravi, Sahithi J Ahmed, Niaz A Taylor, Kirk A Capes, Emily M Bye, Alexander P Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Gibbins, Jonathan M et al.
    Kuravi, Sahithi J, Ahmed, Niaz A, Taylor, Kirk A, Capes, Emily M, Bye, Alexander P, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Gibbins, Jonathan M and Pugh, Nicholas
    (2023) Delineating zinc influx mechanisms during platelet activation. International Journal of Molecular Sciences, 24 (14). p. 11689. ISSN 1422-0067

    Mitchell, Joanne Little, Gemma Bye, Alexander Gasper, Renato Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Kriek, Neline Sage, Tanya et al.
    Mitchell, Joanne, Little, Gemma, Bye, Alexander, Gasper, Renato, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Kriek, Neline, Sage, Tanya, Stainer, Alexander, Sangowawa, Ibidayo, Morrow, Gael, Bastos, Ricardo, Shapiro, Susan, Desborough, Michael, Curry, Nicola, Gibbins, Jonathan, Whyte, Claire, Mutch, Nicola and Jones, Christopher
    (2023) Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Research and Practice in Thrombosis and Haemostasis, 7 (5). p. 100200. ISSN 2475-0379

    Nock, Sophie, Karim, Eima and Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 (2023) Pim kinases: important regulators of cardiovascular disease. International Journal of Molecular Sciences, 24 (14). p. 11582. ISSN 1661-6596

    Posner, Mareike G ORCID logoORCID: https://orcid.org/0000-0002-3156-3071, Dempsey, Nina C ORCID logoORCID: https://orcid.org/0000-0003-2013-6207 and Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 (2023) The benefits of using case study focussed, problem based learning approaches to unit design for Biomedical Science students. British Journal of Biomedical Science, 80. p. 11494. ISSN 0967-4845

    Albayati, Samara, Li, Nailin, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 and Liverani, Elisabetta (2022) Platelet-lymphocyte co-culture serves as an ex vivo platform of dynamic heterotypic cross-talk. Journal of Cell Communication and Signaling, 16 (4). pp. 661-675. ISSN 1873-9601

    Kriek, Neline Nock, Sophie Sage, Tanya Khalifa, Badrija Bye, Alex P Mitchell, Joanne Thomson, Steven et al.
    Kriek, Neline, Nock, Sophie, Sage, Tanya, Khalifa, Badrija, Bye, Alex P, Mitchell, Joanne, Thomson, Steven, McLaughlin, Mark, Jones, Sarah ORCID logoORCID: https://orcid.org/0000-0001-8154-3928, Gibbins, Jonathan and Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984
    (2022) Cucurbitacins elicit anti-platelet activity via perturbation of the actin cytoskeleton and integrin function. Thrombosis and Haemostasis. ISSN 0340-6245

    Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 and Posner, Mareike G ORCID logoORCID: https://orcid.org/0000-0002-3156-3071 (2022) Case study : using H5P to design and deliver interactive laboratory practicals. Essays in Biochemistry, 66 (1). pp. 19-27. ISSN 0071-1365

    Wang, Shengfang Hu, Sining Luo, Xing Bao, Xiaoyi Li, Ji Liu, Minghao Lv, Ying et al.
    Wang, Shengfang, Hu, Sining, Luo, Xing, Bao, Xiaoyi, Li, Ji, Liu, Minghao, Lv, Ying, Zhao, Chen, Zeng, Ming, Chen, Xi, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Jones, Sarah, Johnson, Thomas W, White, Stephen J, Jia, Haibo and Yu, Bo
    (2022) Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction. EBioMedicine, 78. p. 103964. ISSN 2352-3964

    Dunster, Joanne L Bye, Alexander Kriek, Neline Sage, Tanya Kempster, Carly McKinney, Harriet Batista, Joanna et al.
    Dunster, Joanne L, Bye, Alexander, Kriek, Neline, Sage, Tanya, Kempster, Carly, McKinney, Harriet, Batista, Joanna, Thomas, Patrick, Jones, Chris, Downes, Kate, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 and Gibbins, Jonathan
    (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances, 5 (20). pp. 4017-4030. ISSN 2473-9529

    Sahli, Khaled Flora, Gagan Sasikumar, Parvathy Maghrabi, Ali Holbrook, Lisa AlOuda, Sarah Elgheznawy, Amro et al.
    Sahli, Khaled, Flora, Gagan, Sasikumar, Parvathy, Maghrabi, Ali, Holbrook, Lisa, AlOuda, Sarah, Elgheznawy, Amro, Sage, Tanya, Stainer, Alexander, Adiyaman, Recep, AboHassan, Mohammad, Crescente, Marilena, Kriek, Neline, Vayiyapuri, Sakhtivel, Bye, Alexander, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Jones, Christopher, McGuffin, Liam and Gibbins, Jonathan
    (2021) Structural, Functional and Mechanistic Insights Uncover the Fundamental Role of Orphan Connexin-62 in Platelets. Blood, 137 (6). pp. 830-843. ISSN 0006-4971

    Gasper, Renato Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Al-Dibouni, Alaa Bye, Alexander Sage, Tanya Stewart, Michelle Wells, Sara et al.
    Gasper, Renato, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Al-Dibouni, Alaa, Bye, Alexander, Sage, Tanya, Stewart, Michelle, Wells, Sara, Cox, Roger, Gibbins, Jonathan, Sellayah, Dyan and Hughes, Craig
    (2021) Maternal and offspring high‑fat diet leads to platelet hyperactivation in male mice offspring. Scientific Reports, 11 (1). p. 1473. ISSN 2045-2322

    Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Bye, Alexander Sage, Tanya Gasper, Renato Eaton, Nathan Drew, Caleb Stainer, Alexander et al.
    Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Bye, Alexander, Sage, Tanya, Gasper, Renato, Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter, Hutchinson, James, Riley, Ryan, Jones, Sarah, Mundell, Stuart, Cui, Weiguo, Falet, Herve and Gibbins, Jonathan
    (2020) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica: the hematology journal, 105. ISSN 0390-6078

    Dunster, Joanne Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Bye, Alexander Haining, Elizabeth Sowa, Marcin Ying, Di Sage, Tanya et al.
    Dunster, Joanne, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Bye, Alexander, Haining, Elizabeth, Sowa, Marcin, Ying, Di, Sage, Tanya, Pallini, Chiara, Pike, Jeremy, Hardy, Alexander, Nieswandt, Bernard, Garcia, A, Watson, Stephen, Poulter, Natalie, Gibbins, Jonathan and Pollitt, Alice
    (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of GPVI mediated activation. Journal of Thrombosis and Haemostasis, 18 (2). pp. 485-496. ISSN 1538-7933

    Flora, GD Sahli, KA Sasikumar, P Holbrook, LM Stainer, AR AlOuda, SK Crescente, M et al.
    Flora, GD, Sahli, KA, Sasikumar, P, Holbrook, LM, Stainer, AR, AlOuda, SK, Crescente, M, Sage, T, Unsworth, AJ ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 and Gibbins, JM
    (2019) Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific Reports, 9.

    Unsworth, Amanda J, Bye, Alexander P, Kriek, Neline, Sage, Tanya, Osborne, Ashley A, Donaghy, Dillon and Gibbins, Jonathan M (2019) Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets, 30 (6). pp. 762-772. ISSN 0953-7104

    Stainer, Alexander R Sasikumar, Parvathy Bye, Alexander P Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Holbrook, Lisa M Tindall, Marcus Lovegrove, Julie A et al.
    Stainer, Alexander R, Sasikumar, Parvathy, Bye, Alexander P, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Holbrook, Lisa M, Tindall, Marcus, Lovegrove, Julie A and Gibbins, Jonathan M
    (2019) The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects. TH open : companion journal to thrombosis and haemostasis, 3 (3). e244-e258. ISSN 2567-3459

    Unsworth, Amanda Bombik, Izabela Pinto-Fernandez, Adan McGouran, Joanna Konietzny, Rebecca Zahedi, René Watson, Steve et al.
    Unsworth, Amanda, Bombik, Izabela, Pinto-Fernandez, Adan, McGouran, Joanna, Konietzny, Rebecca, Zahedi, René, Watson, Steve, Kessler, Benedikt and Pears, Catherine
    (2018) Human Platelet Protein Ubiquitylation and Changes following GPVI Activation. Thrombosis and Haemostasis, 119 (01). pp. 104-116. ISSN 0340-6245

    Sasikumar, P AlOuda, KS Kaiser, WJ Holbrook, LM Kriek, N Unsworth, AJ ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Bye, AP et al.
    Sasikumar, P, AlOuda, KS, Kaiser, WJ, Holbrook, LM, Kriek, N, Unsworth, AJ ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Bye, AP, Sage, T, Ushioda, R, Nagata, K, Farndale, RW and Gibbins, JM
    (2018) The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis. Journal of Thrombosis and Haemostasis (JTH), 16 (5). pp. 946-959. ISSN 1538-7836

    Unsworth, Amanda J, Flora, Gagan D and Gibbins, Jonathan M (2018) Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular Research, 114 (5). pp. 645-655. ISSN 0008-6363

    Bye, Alexander P Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Desborough, Michael J Hildyard, Catherine AT Appleby, Niamh Bruce, David Kriek, Neline et al.
    Bye, Alexander P, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Desborough, Michael J, Hildyard, Catherine AT, Appleby, Niamh, Bruce, David, Kriek, Neline, Nock, Sophie H, Sage, Tanya, Hughes, Craig E and Gibbins, Jonathan M
    (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529

    Unsworth, Amanda J Bye, Alexander P Tannetta, Dionne S Desborough, Michael JR Kriek, Neline Sage, Tanya Allan, Harriet E et al.
    Unsworth, Amanda J, Bye, Alexander P, Tannetta, Dionne S, Desborough, Michael JR, Kriek, Neline, Sage, Tanya, Allan, Harriet E, Crescente, Marilena, Yaqoob, Parveen, Warner, Timothy D, Jones, Chris I and Gibbins, Jonathan M
    (2017) Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Arteriosclerosis, Thrombosis, and Vascular Biology, 37 (8). pp. 1482-1493. ISSN 1079-5642

    Unsworth, Amanda J Flora, Gagan D Sasikumar, Parvathy Bye, Alexander P Sage, Tanya Kriek, Neline Crescente, Marilena et al.
    Unsworth, Amanda J, Flora, Gagan D, Sasikumar, Parvathy, Bye, Alexander P, Sage, Tanya, Kriek, Neline, Crescente, Marilena and Gibbins, Jonathan M
    (2017) RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arteriosclerosis, Thrombosis, and Vascular Biology, 37 (5). pp. 812-822. ISSN 1079-5642

    Unsworth, AJ, Kriek, N, Bye, AP, Naran, K, Sage, T, Flora, GD and Gibbins, JM (2017) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity. Journal of thrombosis and haemostasis ( JTH), 15 (2). pp. 356-369. ISSN 1538-7933

    Moraes, Leonardo A Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Vaiyapuri, Sakthivel Ali, Marfoua S Sasikumar, Parvathy Sage, Tanya Flora, Gagan D et al.
    Moraes, Leonardo A, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Vaiyapuri, Sakthivel, Ali, Marfoua S, Sasikumar, Parvathy, Sage, Tanya, Flora, Gagan D, Bye, Alex P, Kriek, Neline, Dorchies, Emilie, Molendi-Coste, Olivier, Dombrowicz, David, Staels, Bart, Bishop-Bailey, David and Gibbins, Jonathan M
    (2016) Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. Arteriosclerosis, Thrombosis, and Vascular Biology, 36 (12). pp. 2324-2333. ISSN 1079-5642

    Bye, AP, Unsworth, AJ ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 and Gibbins, JM (2016) Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of Thrombosis and Haemostasis, 14 (5). pp. 918-930. ISSN 1538-7836

    Darby, Richard AJ, Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Knapp, Stefan, Kerr, Ian D and Callaghan, Richard (2015) Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors. Cancer Chemotherapy and Pharmacology, 76 (4). pp. 853-864. ISSN 0344-5704

    Bye, Alexander P, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Vaiyapuri, Sakthivel, Stainer, Alexander R, Fry, Michael J and Gibbins, Jonathan M (2015) Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (11). pp. 2326-2335. ISSN 1079-5642

    Vaiyapuri, Sakthivel Roweth, Harvey Ali, Marfoua S Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Stainer, Alexander R Flora, Gagan D Crescente, Marilena et al.
    Vaiyapuri, Sakthivel, Roweth, Harvey, Ali, Marfoua S, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Stainer, Alexander R, Flora, Gagan D, Crescente, Marilena, Jones, Chris I, Moraes, Leonardo A and Gibbins, Jonathan M
    (2015) Pharmacological actions of nobiletin in the modulation of platelet function. British Journal of Pharmacology, 172 (16). pp. 4133-4145. ISSN 0007-1188

    Vaiyapuri, Sakthivel Sage, Tanya Rana, Rekha H Schenk, Michael P Ali, Marfoua S Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 Jones, Chris I et al.
    Vaiyapuri, Sakthivel, Sage, Tanya, Rana, Rekha H, Schenk, Michael P, Ali, Marfoua S, Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Jones, Chris I, Stainer, Alexander R, Kriek, Neline, Moraes, Leonardo A and Gibbins, Jonathan M
    (2015) EphB2 regulates contact-dependent and contact-independent signaling to control platelet function. Blood, 125 (4). pp. 720-730. ISSN 0006-4971

    Unsworth, AJ ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Finney, BA, Navarro-Nunez, L, Severin, S, Watson, SP and Pears, CJ (2012) Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis. Journal of Thrombosis and Haemostasis (JTH), 10 (9). pp. 1887-1894. ISSN 1538-7836

    Unsworth, Amanda J ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Smith, Holly, Gissen, Paul, Watson, Steve P and Pears, Catherine J (2011) Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca2+. Journal of Biological Chemistry, 286 (24). pp. 21073-21082. ISSN 0021-9258

    Book Section

    Unsworth, AJ ORCID logoORCID: https://orcid.org/0000-0003-3809-5984, Bye, AP and Gibbins, JM (2017) Platelet-Derived Inhibitors of Platelet Activation. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Springer, pp. 541-556. ISBN 9783319474625

    Conference or Workshop Item

    Bye, Alexander, Kriek, Neline, Sage, Tanya, Mitchell, Joanne, Donaghy, Dylan, Gibbins, Jonathan and Unsworth, Amanda ORCID logoORCID: https://orcid.org/0000-0003-3809-5984 (2019) Novel anti-platelet properties of dietary cucurbitacins. In: The Platelet Society Meeting, 12 September 2019 - 13 September 2019, Jesus College, Cambridge. (Unpublished)

    This list was generated on Tue Oct 22 10:21:50 2024 BST.