From Cognitive Function to Treatment Efficacy in Obsessive–Compulsive Disorder: Insights from a Multidimensional Meta-Analytic Approach

Harkin, Ben ORCID: https://orcid.org/0000-0002-1446-9673 and Yates, Alan (2024) From Cognitive Function to Treatment Efficacy in Obsessive–Compulsive Disorder: Insights from a Multidimensional Meta-Analytic Approach. Journal of Clinical Medicine, 13 (16). 4629.

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Abstract

Meta-analysis is a statistical tool used to combine and synthesise the results of multiple independent studies on a particular topic. To this end, researchers isolate important moderators and mediators to investigate their influence on outcomes. This paper introduces a novel approach to meta-analysis, known as multidimensional meta-analysis (mi-MA), to study memory performance in those with obsessive–compulsive disorder (OCD). Unlike traditional meta-analyses, mi-MA allows researchers to extract multiple data points (e.g., using different measures) from single studies and groups of participants, facilitating the exploration of relationships between various moderators while avoiding multicollinearity issues. Therefore, in the first instance, we outline the use of the mi-MA approach to quantify the impact of complex models of memory performance in individuals with OCD. This approach provides novel insights into the complex relationship between various factors affecting memory in people with OCD. By showcasing the effectiveness of mi-MA in analysing intricate data and modelling complex phenomena, the paper establishes it as a valuable tool for researchers exploring multifaceted phenomena, both within OCD research and beyond.