e-space
Manchester Metropolitan University's Research Repository

    FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development

    Guasti, L, Candy Sze, WC, McKay, T, Grose, R and King, PJ (2013) FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Molecular and Cellular Endocrinology, 371. ISSN 0303-7207

    [img]
    Preview

    Available under License Creative Commons Attribution.

    Download (1MB) | Preview

    Abstract

    Developmental signalling pathways are implicated in the formation and maintenance of the adrenal gland, but their roles are currently not well defined. In recent years it has emerged that Sonic hedgehog (Shh) and Wnt/β catenin signalling are crucial for the growth and development of the adrenal cortex. Here we demonstrate that Fibroblast growth factor receptor (Fgfr) 2 isoforms IIIb and IIIc are expressed mainly in the adrenal subcapsule during embryogenesis and that specific deletion of the Fgfr2 IIIb isoform impairs adrenal development, causing reduced adrenal growth and impaired expression of SF1 and steroidogenic enzymes. The hypoplastic adrenals also have thicker, disorganised capsules which retain Gli1 expression but no longer express Dlk1. Fgfr2 ligands were detected in both the capsule and the cortex, suggesting the importance of signalling between the capsule and the cortex in adrenal development.

    Impact and Reach

    Statistics

    Activity Overview
    6 month trend
    218Downloads
    6 month trend
    302Hits

    Additional statistics for this dataset are available via IRStats2.

    Altmetric

    Actions (login required)

    View Item View Item